Focusrite Scarlett 16i16 (4th Gen) review

Checked September 2026

Focusrite

Focusrite Scarlett 16i16 (4th Gen) review

Audio interfaces

A 16-in, 16-out USB-C interface with ADAT, S/PDIF and MIDI. Best for home studios expanding with ADAT gear. Price: $409.99.

Focusrite Scarlett 16i16 (4th Gen) by Focusrite

Key features

2 mic/line/instrument preamps
ADAT and S/PDIF in/out
MIDI in/out
2 headphone outputs
Alt speaker switching
24-bit/192 kHz

Pros

Digital expansion via ADAT
Two headphone outputs
Bus-powered

Cons

No talkback microphone

Focusrite Scarlett 16i16 (4th Gen) alternatives

Focusrite
Focusrite Scarlett Solo (4th Gen)
$159.99once
A 2-in, 2-out USB-C interface with one mic preamp and one dedicated guitar input.
VST3not supportedAUnot supportedAAXnot supportedCLAPnot supportedWINsupportedMACsupportedLNXnot supported
Focusrite
Focusrite Scarlett 2i2 (4th Gen)
$224.99once
A 2-in, 2-out USB-C interface with two mic preamps and Auto Gain.
VST3not supportedAUnot supportedAAXnot supportedCLAPnot supportedWINsupportedMACsupportedLNXnot supported
Focusrite
Focusrite Scarlett 4i4 (4th Gen)
$309.99once
A 4-in, 4-out USB-C interface with MIDI I/O and two mic preamps.
VST3not supportedAUnot supportedAAXnot supportedCLAPnot supportedWINsupportedMACsupportedLNXnot supported

All Focusrite Scarlett 16i16 (4th Gen) alternatives